Unfortunately, just about all of the ebook compilers depend on IE being installed. The user doesn't actually open IE, it's just that certain elements of it are used.
I'd suggest downloading the demo and making a small sample ebook that you can send to a few friends that use Opera/FireFox. Chances are they won't have a problem because few (very few) people uninstall IE from their system.
As far as the end user is concerned they won't even know that they are using IE.
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